Background: This work aims at describing the traditional uses, to determine the antimicrobial potential of two different extracts hexane, acetone
of the leaves of
Citrus unshiu
,
Citrus sinensis
,
Citrus limon
,
Laurus nobilis
,
Citrus paradisi
on clinical strain of
H. pylori in a bid to identify
potential sources of cheap starting materials for the synthesis of new drugs.
H. pylori strain was a culture collection of Hacettepe University,
Turkey.
Methods: The activity was quantitatively assessed on the basis of the inhibition zone, and their activity index was also calculated along with the
MIC method.
Results: All the plants demonstrated antimicrobial activity against
H. pylori with zone of inhibition diameters ranging from 0 - 30 mm and
minimum inhibitory concentration (MIC) values ranging from 1:512- 1:4096 dilutions.
Conclusion: The results may serve as scientific validation of the ethnomedicinal uses of the
Citrus unshiu, Citrus sinensis, Citrus limon, Laurus
nobilis, and
Citrus paradisi in the treatment of
H. pylori-related infections. However, further investigations would be necessary to determine their
toxicological properties, in-vivo potencies and mechanism of action against
H. pylori.
