Background: Bergenia purpurascens
has tonic, haemostatic and anti-tussive actions. Anti-inflammatory and anti-bacterial activities of
Bergenia purpurascens have not been reported so far. The objective of this paper is to provide experimental basis for the clinical application of
Bergenia purpurascens through the pharmacodynamic study on its anti-inflammatory and anti-bacterial effects.
Methods: Experimental models of xylene-induced ear edema in mice, cotton pellet granuloma in rats, and acetic acid-induced peritoneal capillary
permeability in mice were used to investigate the anti-inflammatory effect of
Bergenia purpurascens; bacteriostatic and bactericidal effects of
Bergenia purpurascens extract on
Staphylococcus aureus
(SA), methicillin-resistant
Staphylococcus aureus (MRSA), and β-lactamase positive
Staphylococcus aureus (ESBLs-SA), were observed
in vitro.
Results: The results show that
Bergenia purpurascens extract could markedly inhibit xylene-induced mouse ear edema, cotton pellet granulation
tissue hyperplasia, and increased capillary permeability. Bergenia
purpurascens extract has an inhibitory effect on SA, MRSA and ESBLs-SA.
Conclusion: We conclude that
Bergenia purpurascens extract has certain anti-inflammatory and anti-bacterial effects.
