Background: Through research it is found that the barks, stems, fruits and flowers of
Eucommia ulmoides
contain various compositions, such as
lignin, cycloalkane and phenylpropanoids. The modern pharmacological research shows that
Eucommia ulmoides has many functions, such as
anti-aging, antitumor and bone cell proliferation. This paper studied the resin purification process optimization conditions and antihypertensive
effect of
Eucommia ulmoides Oliver.
Materials and Methods: The orthogonal experiment method was adopted to determine the purification effect of various macro-porous resins for
Eucommia ulmoides Oliver, and the SHR model was used to determine antihypertensive level of
Eucommia ulmoides Oliver.
Results: The optimal process of resin extraction and purification of
Eucommia ulmoides Oliver was verified through the loading liquid
concentration at 6 mg/ml, 20% ethanol used as the eluent; the flow rate control was 3.0, column volume per hour and the diameter-height ratio of
adsorption column was 1:6; the extracts of
Eucommia ulmoides Oliver can reduce SHR blood pressure, its antihypertensive effect is relatively
stable and has no significant impact on HR, but the antihypertensive effect is lower than that of control medicine captopril. Also, the extracts of
eucommia ulmoides Oliver can significantly increase the content of serum NO and reduce the content of ET.
Conclusion: The
Eucommia ulmoides Oliver can relax blood vessels, reduce the peripheral resistance, reduce the returned blood volume, and
eventually achieve the antihypertensive effect.
