Background: A pharmaco-chemical investigation of the
Euphorbia cyparissias
plant was justified by its known multiple therapeutic valences.
Numerous components from extracts and latex of Euphorbiacae were identified, revealing a large plant family with a polyvalent therapeutic
activity.
Materials and Methods: The aim of the study was to assess the skin tolerance level to irritation on different testing concentrations, of
Euphorbia
cyparissias extracts and ointments. Study was accomplished in rats and dogs, with the identification of all possible skin injuries and histological
changes, after a simple patch test methodology.
Results: Ointment dermatological testing on rats, proved to be bearable on epilated skin at concentrations of 1, 2 and 5%. Ointments and mother
tincture with higher concentrations (10% and 20%), led to irritation and cutis damages, and this was revealed through histology.
Conclusion: Ointment tested on dog’s skin was tolerable for epilated skin to concentrations of 1, 2 and/or 5%, additional testing on human
volunteers confirmed the same situation.
