Background: Zanthoxylum bungeanum
-cake-separated moxibustion (ZBCS-moxi), a kind of traditional therapy of moxibustion, has been used
in China since 340 B.C. However, its mechanism remains unclear. So, this study was attempted to reveal the anti-inflammatory effect of
ZBCS-moxi on rheumatoid arthritis (RA) rats.
Methods and Materials: Forty health SD female rats were randomly divided into 4 groups (n=10/group): control group, model group,
Zanthoxylum bungeanum-cake-separated moxibustion group (ZBCS-moxi group) and
Aconitum carmichaeli
-cake-separated moxibustion group
(ACCS-moxi group). RA model was induced by injecting 0.1 ml Freund’s complete adjuvant (FCA) into the right hind paw of rats. Eleven days
after CFA injection, the rats in ZBCS-moxi group received
Zanthoxylum bungeanum- cake-separated moxibustion on Shenshu (BL23), Zusanli
(ST36) acupoints and the dorsum right hind paw respectively for 3 weeks. The ACCS-moxi group was used as a positive control, while the rats
were treated with
Aconitum carmichaeli-cake-separated moxibustion on the same acupoints and courses. After a 3-week treatment, we
investigated anti-inflammatory effect by measuring the paw volume, observing the pathologic morphology of synovial membranes and detecting
the concentration of IL-1β and TNF-α in serum.
Results: Compared to model group, the swollen paw volumes, the synovial hyperplasia and pannus formation of synovial membranes and the
concentration of IL-1β and TNF-α in serum decreased obviously (
P<0.01,
P<0.05) in ZBCS-moxi group, as well as in ACCS-moxi group.
However, the swollen paw volumes, the synovial hyperplasia and pannus formation of synovial membranes and the concentration of IL-1β and
TNF-α in serum in ZBCS-moxi and ACCS-moxi group did not show significant differences (
P>0.05)
Conclusions: ZBCS-moxi displays anti-inflammatory effect on RA rats via suppressing the expression of cytokines and has similar effect to
ACCS-moxi.
