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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 13, No. 5, 2016, pp. 67-71
Bioline Code: tc16117
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 13, No. 5, 2016, pp. 67-71

 en ANTI-QUORUM SENSING ACTIVITY OF SOME MEDICINAL PLANTS
Al-Haidari, Rwaida A.; Shaaban, Mona I.; Ibrahim, Sabrin R.M. & Mohamed, Gamal A.

Abstract

Background: Quorum sensing is the key regulator of virulence factors of Pseudomonas aeruginosa check for this species in other resources such as biofilm formation, motility, productions of proteases, hemolysin, pyocyanin, and toxins. The aim of this study was to explore the effect of the extracts from some medicinal plants on quorum sensing and related virulence factors of P. aeruginosa.
Material and Methods: Quorum sensing inhibitory (OSI) effect of the alcohol extracts of 20 medicinal plants was evaluated by Chromobacterium violaceum reporter using agar cup diffusion method. The efficient QSI extracts were tested for their activity against biofilm synthesis, motility, and synthesis of pyocyanin from P. aeruginosa PA14
Results: The extracts of Citrus sinensis check for this species in other resources , Laurus nobilis check for this species in other resources , Elettaria cardamomum check for this species in other resources , Allium cepa check for this species in other resources , and Coriandrum sativum check for this species in other resources exhibited potent quorum quenching effect. On the other hand, Psidium guajava check for this species in other resources and Mentha longifolia check for this species in other resources extracts showed lower QSI activity. These extracts exhibited significant elimination of pyocyanin formation and biofilm development of Pseudomonas aeruginosa check for this species in other resources PA14. In addition, they significantly inhibited twitching and swimming motilities of P. aeruginosa PA14.
Conclusion: This study illustrated, for the first time, the importance of C. sinensis, L. nobilis, E. cardamomum, A. cepa, and C. sativum as quorum sensing inhibitors and virulence suppressors of P. aeruginosa. Thus, these plants could provide a natural source for the elimination of Pseudomonas pathogenesis check for this species in other resources .

Keywords
Quorum sensing inhibitory activity; P. aeruginosa; Chromobacterium violaceum; virulence factors

 
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