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Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 29, No. 3, 2008, pp. 335-345
Bioline Code: zr08054
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 29, No. 3, 2008, pp. 335-345

 en Mammalian Models Based on RCAS-TVA Technique
NIU, Yi-dong & LIANG, Shu-long


The retroviral vector (RCAS) has been widely used in avian system to study development and diseases, but is not suitable for mammals which do not produce the retrovirus receptor TVA. In this review, we trace the current uses of RCAS-TVA approach in mammalian system with improved strategies, including generation of tv-a transgenic mice, use of soluble TVA receptor and retroviral receptor-ligand fusion proteins, improvement of RCAS vectors, and compare a series of mammalian models in variant studies of gene function, development, oncogenesis and gene therapy. All those studies demonstrate that the RCAS-TVA based mammalian models are powerful tools for understanding the mechanisms and target treating of human diseases.

RCAS vector; TVA; Specific promoter; Transgenic animal; Mammalian model

© Copyright 2008 Kunming Institute of Zoology, the Chinese Academy of Sciences
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