About Bioline  All Journals  Testimonials  Membership  News  Donations

Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 30, No. 2, 2009, pp. 199-203
Bioline Code: zr09031
Full paper language: Chinese
Document type: Research Article
Document available free of charge

Zoological Research, Vol. 30, No. 2, 2009, pp. 199-203

 en Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection
Liu, Xiao-fen; Yan, Zi-li; Wang, Jian-hong; Hu, Xin-tian & Ma, Yuan-ye


Acute drug use modifies brain function in critical ways, and prolonged drug use causes pervasive changes in brain function that persist long after withdrawal. Our previous studies proved that acute or four-day morphine injection impaired mice spatial recognition memory in the Y-maze, but the impairment was short and reversible. In the present study, morphine or saline (40 mg/ kg·day, ip) was injected into mice for 21 days. Spatial recognition memory was tested in the Y-maze on the 2nd, 9th and 19th withdrawal day. Our results showed that spatial recognition memory of morphine-injected mice was impaired on each of the three test days. Our study clearly suggests that long-term morphine use leads to more persistent impairments of spatial recognition memory.

Y-maze Spatial recognition memory Morphine Withdrawal Withdrawal symptoms

© Copyright 2009 Kunming Institute of Zoology, the Chinese Academy of Sciences
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 19-Jan-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil