|
Zoological Research
Kunming Institute of Zoology, Chinese Academy of Sciences
ISSN: 2095-8137
Vol. 33, No. 2, 2012, pp. 165-169
|
Bioline Code: zr12025
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Zoological Research, Vol. 33, No. 2, 2012, pp. 165-169
en |
Effects of odor cue on morphine-induced dependence and craving in mice
LIU, Xiao-Fen; YANG, Guang; YANG, Rui; JIA, Qiang & GUAN, Su-Dong
Abstract
The olfactory system may play a pivotal role in drug addiction. To clarify the issues, we investigated the
morphine dependence and psychological craving in morphine addicted mice using the conditioned place preference (CPP)
paradigm by taking an only odor cue as the conditioned stimulus (CS). The results showed that by pairing morphine with
odor, the CPP could be induced in mice. When the morphine addicted mice were exposed to a novel environment during
morphine withdrawal, they spent significantly longer time in the chamber with morphine-paired odor than in the control
chamber. The effects of odor cue on the morphine CPP were blocked by the administration of dopamine D1 or D2
antagonists. The studies indicated that olfactory system plays an important role in drug addiction.
Keywords
Drug addiction; Morphine-induced dependence; Dopamine; Odor cue; CPP
|
|
© Copyright 2012 - Kunming Institute of Zoology, the Chinese Academy of Sciences Alternative site location: http://www.zoores.ac.cn/
|
|