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Reconstructing gene regulatory networks in single-cell transcriptomic data analysis Dai, Hao; Jin, Qi-Qi; Li, Lin & Chen, Luo-Nan Abstract Gene regulatory networks play pivotal roles in our understanding of biological processes/mechanisms at the molecular level. Many studies have developed sample-specific or cell-type-specific gene regulatory networks from single-cell transcriptomic data based on a large amount of cell samples. Here, we review the state-of-the-art computational algorithms and describe various applications of gene regulatory networks in biological studies. Keywords Gene regulatory network; Single-cell RNA sequencing; Computational algorithm; Sample-specific network; Cell-type-specific network; Cell-specific network

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