Mouse models of epithelial ovarian cancer for preclinical studies

Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations.

Keywords
Epithelial ovarian cancer; Patient-derived xenografts; Orthotopic mouse model; Subcutaneous mouse model; Intraperitoneal mouse model; Syngeneic mouse model; Genetic engineered mouse model