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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323 EISSN: 0973-3922
Vol. 69, Num. 5, 2003, pp. 363-364
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Untitled Document
Indian Journal of Dermatology, Venerelogy & Leprology, Vol 69, No.
5 ,Sept-Oct, 2003, pp. 363-364
Letters to Editor
Response by the authors
Smita Prabhu, S. D. Shenoi
Deartment of Skin & STD, Kasturba Medical
College & Hospital, Manipal, India.
Code Number: dv03066
Sir,
We wish to thank Dr M. J. Cyriac for spotting
the error and enlightening the readers about the interaction of cyclosporin
with grapefruit and not grape juice. We
are happy that our article has been thoroughly scrutinized.
A point to be noted is that although sweet orange
juice is safe, a variety of sour oranges used in marmalades
called Seville oranges contain 6,7 dihydroxybergamottin, the furanocoumarin
compound found in grapefruit. However a recent study1 has not found
interaction of Seville orange juice with cyclosporine.
Reference
- Edwards DJ, Fitzsimmons ME, Schuetz EG
et al. 6, 7 dihydroxybergamottin in grapefruit juice and Seville orange juice:
effects on cyclosporine disposition, enterocyte CYP3A4 and P-glycoprotein.
Clin Pharmacol Ther 1999;65: 237-44.
Copyright 2003 - Indian Journal of Dermatology, Venereology & Leprology.
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