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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482 EISSN: 0973-1482
Vol. 1, No. 1, 2005, pp. 21-30
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Bioline Code: cr05006
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Cancer Research and Therapeutics, Vol. 1, No. 1, 2005, pp. 21-30
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Review Article - Management of locally advanced breast cancer: Evolution and current practice
Rustogi Ashish, Budrukkar Ashwini, Dinshaw Ketayun, Jalali Rakesh
Abstract
Locally advanced breast cancer (LABC) accounts for a sizeable number (30-60%) of breast cancer cases and is a common clinical scenario in developing countries. The treatment of LABC has evolved from single modality treatment, consisting of radical mutilating surgery or higher doses of radiotherapy in inoperable disease to multimodality management, which along with the above two included systemic therapy. Neoadjuvant chemotherapy (NACT) has made a tremendous impact on the management of LABC. NACT was initiated to institute systemic therapy upfront at the earliest in this group of patients with a high risk of micrometastasis burden. While NACT did not yield a survival advantage, it has however made breast conservation possible in selected group of cases. Large number of studies and many randomised trials have been done in women with LABC in order to improve the therapeutic decisions and also the local control and survival. With this background we have reviewed various treatment options in patients with LABC which should possibly help in guiding the clinicians for optimal management of LABC.
Keywords
Locally advanced breast cancer, neoadjuvant chemotherapy, breast conservation therapy
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© Copyright 2005 Journal of Cancer Research and Therapeutics. Alternative site location: http://www.cancerjournal.net/
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