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Journal of Cancer Research and Therapeutics
Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)
ISSN: 0973-1482 EISSN: 0973-1482
Vol. 3, No. 2, 2007, pp. 81-85
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Bioline Code: cr07021
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Cancer Research and Therapeutics, Vol. 3, No. 2, 2007, pp. 81-85
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A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer
Haresh, KP; Julka, PK; Sharma, DN; Rath, GK; Prabhakar, R & Seth, A
Abstract
Aim : The aim of our study was to compare the two standard treatment approaches in muscle invasive carcinoma of urinary bladder - radical cystectomy and chemo radiation.
Materials and Methods : Transitional cell carcinoma (TCC) of bladder of stages, T2 to T4, N0/N1/N2 and MO were included in the study. Patients were allotted to two arms of the study. Arm A consisted of radical cystectomy. Adjuvant CMV chemotherapy was given for T3/T4 or Node positive disease only. Arm B received 2 cycles of neoadjuvant CMV chemo therapy followed by concurrent chemo radiation
Results : Forty-four patients were recruited into the study. Thirty patients in the surgical arm and 13 patients in the chemo radiation arm. The actuarial two-year survival rate in surgical arm is 56% while in chemo radiation arm it is 54%. There was no statistically significant difference in disease-free survival also between the two groups.
Conclusion : Chemo radiation yielded equivalent survival results with radical cystectomy. So it is worth giving preference to chemo radiation that will give a better quality of life for the patient.
Keywords
Chemo radiation, muscle invasive bladder cancer, radical cystectomy
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© Copyright 2007 Journal of Cancer Research and Therapeutics. Alternative site location: http://www.cancerjournal.net/
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