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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 2, No. 4, 2005, pp. 140-143
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Bioline Code: gm05031
Full paper language: English
Document type: Research Article
Document available free of charge
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European Journal of General Medicine, Vol. 2, No. 4, 2005, pp. 140-143
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MECHANISM OF ACTION OF JATROPHA GOSSYPIFOLIA STEM LATEX AS A HAEMOSTATIC AGENT
Taofeeq Oduola, Ganiyu Oyebola Adeosun, Tesleem Aderemi Oduola, Godwin Ovie Avwioro, Mutiyat Adeyoola Oyeniyi
Abstract
Aim:
Jatropha gossypifolia belongs to the family "Euphorbiacea". The coagulant activity and the mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent were investigated.
Methods:
The mechanism of action was investigated using doubling dilution technique by mixing neat (undiluted) and serial dilutions of the latex with 30% bovine albumin.
Results:
The results of whole blood clotting time using Lee and White method and bleeding time using Ivy's method were significantly reduced (P < 0.05) when stem latex was introduced than when the tests were performed without stem latex. This means that the stem latex possesses procoagulant activity.
Conclusion: The result of this test showed that precipitation of coagulant factors is the mechanism of action of its haemostatic activity.
Keywords
Jatropha gossypifolia, haemostatic agent, mechanism.
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