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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 4, No. 4, 2007, pp. 176-179
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Bioline Code: gm07041
Full paper language: English
Document type: Research Article
Document available free of charge
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European Journal of General Medicine, Vol. 4, No. 4, 2007, pp. 176-179
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Investigation Of Anti-Inflammatory Activity Of Bergamot Oil
Karaca, Mehmet; Özbek, Hanefi; Him, Aydın; Tütüncü, Mehmet; Akkan, Hasan Altan & Kaplanoğlu, Veysel
Abstract
Aim:
Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using
carrageenan-induced rat paw oedema test.
Methods:
For the anti-inflammatory activity measurement six different groups were established
and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was
used as a reference agent.
Results:
It was found that reduction in the inflammation was 95.70% with indomethacin,
27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO.
Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The
strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective
dose (ED50) value of BO was found to be 0.079 mL/kg.
Conclusion:
The results showed that BO posseses promising anti-inflammatory effect.
Keywords
Citrus aurantium subsp. bergamia, Bergamot oil, anti-inflammatory activity, carrageenan-oedema.
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