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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 6, No. 2, 2009, pp. 103-107
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Bioline Code: gm09023
Full paper language: English
Document type: Research Article
Document available free of charge
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European Journal of General Medicine, Vol. 6, No. 2, 2009, pp. 103-107
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Serum TNF-Alpha Levels in Acute and Chronic Pancreatitis
Kıyıcı, Aysel; İbiş, Mehmet; Akbulut, Şeval; Köklü, Seyfettin; Uçar, Engin & Ünlü, Ali
Abstract
Aim:
Acute and chronic pancreatitis are inflammations of pancreatic
tissue which have systemic effects and clinical presentations
such as bacteremia and septic shock. Inflammatory markers have
growing importance in diagnosis and identification of the severity
of the pancreatitis. We aimed to determine TNF-alpha levels in
acute and chronic pancreatitis and evaluate the relation between
TNF-alpha levels and the pancreatic enzyme concentrations in two
forms of the disease.
Methods:
13 patients with acute pancreatitis, 36 patients with
chronic pancreatitis and 14 healthy controls were included to
our study. TNF-alpha determinations were performed with ELISA
method.
Results:
TNF-alpha concentrations were 13.30±4.42 (7.04-21.35)
pg/ml and 9.88±4.68 (3.99-27.73) pg/ml 10.09±1.01 (8.69-14.96)
pg/ml in patients with acute and chronic pancreatitis and healthy
controls respectively. TNF-alpha concentrations were significantly
higher in patients with acute pancreatitis than the patients with
chronic pancreatitis. But there was no significant difference between
healthy controls and patients with either acute or chronic
pancreatitis for TNF-alpha levels. There was no significant correlation
between TNF-alpha concentrations and pancreatic enzyme
levels.
Conclusion:
We concluded that in acute pancreatitis TNF-alpha levels
were higher than the chronic form of the disease. But its concentrations
did not correlate with the severity of the disease. By
investigation of the other inflammatory markers and acute phase
reactants with TNF-alpha, this process will be more clarified.
Keywords
TNF-alpha, acute pancreatitis, chronic pancreatitis
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