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The Journal of Health, Population and Nutrition
icddr,b
ISSN: 1606-0997 EISSN: 1606-0997
Vol. 30, No. 4, 2012, pp. 487-490
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Bioline Code: hn12056
Full paper language: English
Document type: Report
Document available free of charge
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The Journal of Health, Population and Nutrition, Vol. 30, No. 4, 2012, pp. 487-490
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Ampicillin and Gentamicin Are a Useful First-line Combination for the Management of Sepsis in Under-five Children at an Urban Hospital in Bangladesh
Bibi, Samira; Chisti, Mohammod Jobayer; Akram, Farhana & Pietroni, Mark A.C.
Abstract
The study evaluated the commonly-used drugs for the management of sepsis and their outcome
among under-five children. We evaluated the hospital-records of all paediatric sepsis patients (n=
183) in the intensive care unit (ICU) and longer-stay unit (LSU) of the Dhaka Hospital of icddr,b.
These records were collected from the hospital management system (SHEBA) during November
2009 to October 2010. A total of 183 under-five children with clinical sepsis were found during
the study period, and 14 (8%) of them were neonates. One hundred and eighty-one patients had
received a combination of injection ampicilin and injection gentamicin, and two patients had received
the combination of injection ceftriaxone and injection gentamicin. Only 46 (25%) patients
required a change of antibiotics to the combination of intravenous ceftriaxone plus gentamicin
after non-response of injection ampicilin and injection gentamicin combination; 7/181 (4%) patients
died who received injection ampicilin and injection gentamicin whereas none died among
the other two patients who received injection ceftriaxone and injection gentamicin (p=1.00). The
combination of injection ampicilin and injection gentamicin as the first-line antibiotics for the
management of sepsis in children even beyond the neonatal age is very effective, resulting in
lower mortality.
Keywords
Antibiotics; Children; Diarrhoea; Infant; Sepsis; Bangladesh
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