en |
Combined Effects of Aqueous Extracts of Xylopia aethiopica and Monodora myristica Seeds on Lipid Profile and Haematological Indices in Rats Exposed to Cyanide
KADIRI, HE
Abstract
The purpose of this study was to determine combined effect of Xylopia aethiopica seed (Xa) and
Monodora myristica seed extracts (Mm) on haematological parameters{pack cell volume (PCV), haemoglobin (Hb) , red
blood cell count (RBC) and white blood count (WBC) } and lipid profile {Total cholesterol (TC), triglycerides (TG), high-density
lipoproteins (HDL) and low-density lipoproteins (LDL) }in cyanide exposed rats. The study was conducted using 32
male rats weighing between 120 to 150 g. The rats were divided into 8 groups of 4 rats in each group as follows; Group 1:
(control), Group 2: cyanide control (exposed to cyanide only), Group 3: given Xa only, Group 4: given Mm only, Group 5:
Xa+ Mm mixture only, Group 6: cyanide + Xa, Group 7: cyanide + Mm and Group 8: cyanide plus (Xa+Mm). The rats
in Groups 3-8,were given the spice extracts 60mg (Xa, Mm and Xa+Mm mixture) at 1ml/kg three times per week, and Rats
in Groups 2, 6, 7 and 8 received CN in form of NaCN solution at concentration of 9.0 mg/kg in the drinking tap water every
day for 4 weeks. The results showed that the haematological parameters (PCV, HB, RBC and WBC) was significantly
(p>0.05) increased in all the Groups treated with the Xa and Mm extracts (Groups 6, 7 and 8) when compared with the
untreated Group 2. However there was no significant difference in the haematological parameters between the groups given
the mixture of the two plant extracts Group 8 (Xa +Mm) and those given the two extracts separately Group 6 and 7). Results
from the lipid profile indicated a significant decrease TC, LDL and TG in all the cyanide exposed rats treated with the extracts
(Group 6, 7 and 8) when compared with the untreated Group 2, However a significantly lower TC, LDL and TG was indicated
in Group 8 rats given the mixture when compared with Group 6 and 7 given Xa and Mm separately. In conclusion, the result
indicates that although both extracts are able to improve the haematological and lipid profile parameters in cyanide exposed
rats, the combined extracts (Xa+ Mm) gave better results in the lipid profile compared with the individual plant extracts in
cyanide exposed rats.
Keywords
Monodora myristica; Xylopia aethiopica; cyanide; lipid profile.
|