As pathogens in recent times have developed resistance to the existing antibiotics, the demand for new
and more effective antimicrobial agents is a continuous phenomenon. The study involves the synthesis of schiff base from
5-bromo- salicylaldehyde and para-toluidine.The synthesized compounds (5-Bromo – Salicylaldehyde and the Schiff
base-N-(5-bromo-2-hydroxybenzylidene) Para-toluidine) were evaluated for antimicrobial activities against different
bacteria strains using the agar well diffusion method. The 5-bromosalicylaldehyde and its Schiff base indicated dose
dependent activity as concentration increases from 125mg/ml to 1000mg/ml and inhibitory zones were found to increase
mostly for
Escherichia coli
. The two compounds synthesized have indicated high antimicrobial activities on the selected
germs and as such can be a drug precursor to microbial infections with further research.