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Journal of Medicine and Biomedical Research
College of Medical Sciences, University of Benin
ISSN: 1596-6941
Vol. 3, No. 1, 2004, pp. 37-41
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Bioline Code: jm04005
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Medicine and Biomedical Research, Vol. 3, No. 1, 2004, pp. 37-41
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Correlation between cyanide-induced decreases in ocular Ca2+-ATPase and lenticular opacification
Okolie, NP & Audu, K
Abstract
The effect of cyanide toxicity on Ca2+-ATPase activities were significantly decreased in the lens and vitreous humour of the cyanide-fed rabbits (p< 0.05), while the corneal enzyme was unaffected. Ophthalmoscopic examination of the cyanide-exposed rabbits revealed adverse morphological changes, including pale fundus, low retinal reflex and lenticular opacification. The results suggest that cyanide-induced cataractogenesis may be a consequence of disruption of vitreous humour and lenticular calcium homeostasis.
Keywords
Cyanide, Ca2+-ATPase, cataracts
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