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Journal of Postgraduate Medicine
Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
ISSN: 0022-3859 EISSN: 0022-3859
Vol. 48, No. 1, 2002, pp. 5-10
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Bioline Code: jp02002
Full paper language: English
Document type: Research Article
Document available free of charge
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Journal of Postgraduate Medicine, Vol. 48, No. 1, 2002, pp. 5-10
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ß2-Glycoprotein I Dependent Anticardiolipin Antibodies and Lupus Anticoagulant in Patients With Recurrent Pregnancy Loss
Kumar KSD, Jyothy A, Prakash MS, Rani HS, Reddy PP
Abstract
AIM: The present study was aimed to define the incidence of antiphospholipid antibodies
of different types lupus anticoagulant (LAC), venereal disease research laboratory
test (VDRL) and ß2-glycoprotein I dependent anticardiolipin antibodies (ß2
I aCL) in our cohort of population experiencing recurrent pregnancy loss (RPL)
from Andhra Pradesh, South India. SETTING AND DESIGN: A referral case-control
study at a tertiary centre over a period of 5 years. PARTICIPANTS: 150 couples
experiencing 3 or more recurrent pregnancy losses with similar number of matched
controls. MATERIAL AND METHODS: LAC activity was measured by the activated partial
thromboplastin time (aPTT) according to the method of Proctor and Rapaport with
relevant modifications. VDRL analysis was performed by the kit method supplied
by Ranbaxy Diagnostics Limited and ß2 Glycoprotein I dependant anticardiolipin
antibodies were estimated by ELISA kit (ORGen Tech, GmbH, Germany) with human
ß2 Glycoprotein I as co-factor. STATISTICAL ANALYSIS: Statistical analysis
was performed using Student's t test. RESULTS: LAC activity was found positive
in 11 women (10.28%). The mean ± SE ß2 I aCL concentration in the study
group was 14.53 (u/ml) ± 1.79 (range 0 to 90.4 u/ml) which was higher than
the control group with a mean ± SE of 7.26 (u/ml) ± 0.40 (range 0 to
18 u/ml). The binding of the antibodies to the antigen was observed in 40.24%
(n=33) of the cases compared to 6.09% (n=5) in controls. VDRL test was positive
in 7(2.34%) individuals (3 couples and 1 male partner) and none among controls.
CONCLUSIONS: The present study indicates the importance of antiphospholipid antibodies
in women experiencing RPL and suggests the usefulness of screening for these antibodies
as a mandatory routine for instituting efficient therapeutic regimens for a successful
outcome of pregnancy.
Keywords
Antiphospholipid antibodies, Antiphospholipid syndrome, ß2-glycoprotein I dependent anticardiolipin antibodies, Lupus anticoagulant, Recurrent pregnancy loss.
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