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Journal of Postgraduate Medicine
Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
ISSN: 0022-3859 EISSN: 0022-3859
Vol. 54, No. 2, 2008, pp. 135-137
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Bioline Code: jp08045
Full paper language: English
Document type: Case Report
Document available free of charge
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Journal of Postgraduate Medicine, Vol. 54, No. 2, 2008, pp. 135-137
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Hypereosinophilic syndrome with isolated Loeffler's endocarditis: Complete resolution with corticosteroids
Sen, T; Ponde, CK & Udwadia, ZF
Abstract
Hypereosinophilic syndrome (HES) is classically defined as prolonged, unexplained peripheral eosinophilia in a patient presenting with evidence of end-organ damage. The heart is involved in two forms; endomyocardial fibrosis (Davies disease) and eosinophilic endocarditis (Loffler′s endocarditis). It was first reported in 1968 by Hard and Anderson. Chusid and co-workers formulated a definition with strict criteria for the diagnosis of HES as 1) peripheral blood eosinophilia more than 1500 cells/cu mm for at least six months duration 2)signs, symptoms of end-organ (heart, lungs, gastrointestinal tract, skin, bone-marrow, brain) involvement with eosinophil tissue infiltration/injury 3) exclusion of known secondary causes of eosinophilia. We report a case of hypereosinophilic syndrome with Loffler′s endocarditis, in the absence of endomyocardial fibrosis. The patient presented with a eosinophilic vegetation over the posterior leaflet of the mitral valve. There was complete resolution of the vegetation after two months of corticosteroid therapy.
Keywords
Hypereosinophilic syndrome, Loeffler′s endocarditis, response to steroids
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