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Journal of Postgraduate Medicine
Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
ISSN: 0022-3859 EISSN: 0022-3859
Vol. 55, No. 4, 2009, pp. 296-300
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Bioline Code: jp09096
Full paper language: English
Document type: Review Article
Document available free of charge
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Journal of Postgraduate Medicine, Vol. 55, No. 4, 2009, pp. 296-300
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Deflazacort
Joshi, N. & Rajeshwari, K.
Abstract
Conventional oral steroids like prednisolone have various adverse effects both during short-term and long-term use. Hence a search for an alternative oral steroid with fewer side-effects is underway throughout the world. Deflazacort, an oxazoline derivative, is a step in this direction. The number of large randomized trials using deflazacort for steroid-responsive disorders in children is limited. Use of deflazacort has been explored largely in patients with Duchenne′s muscular dystrophy. Preliminary data suggest reduced osteoporosis, lesser growth retardation and weight gain with use of deflazacort, as compared to other steriods. In view of the limited data demonstrating superiority of deflazacort over the available oral steroids and its prohibitive cost, it is early to advocate widespread use of this drug in children.
Keywords
Children, deflazacort, efficacy, safety, usage
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