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East and Central African Journal of Surgery
Association of Surgeons of East Africa and College of Surgeons of East Central and Southern Africa
ISSN: 1024-297X EISSN: 1024-297X
Vol. 17, No. 3, 2012, pp. 3-11
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Bioline Code: js12043
Full paper language: English
Document type: Research Article
Document available free of charge
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East and Central African Journal of Surgery, Vol. 17, No. 3, 2012, pp. 3-11
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Aetiology and Impact of Intra-abdominal Sepsis on Surgical Management
Weledji, E.P. & Cnichom, A.M.
Abstract
An overview of intra-abdominal sepsis is necessary at this time with new experimental studies and audits
on management outcomes. The understanding of the pathophysiology of the peritoneum in the
manifestation of surgical sepsis and the knowledge of the source of pathogenic organisms which reach the
peritoneal cavity are crucial to the prevention of intra-abdominal infection. Recent advances in
interventional techniques for peritonitis have significantly reduced the morbidity and mortality of
physiologically severe complicated abdominal infection. Sepsis is an evolving process and the sequelae
reflect the increasing severity of the systemic response to infection. Prevention entails early recognition,
prompt resuscitation and early surgical intervention to abort the process. Sepsis represents a major clinical
challenge and their management demands a multidisciplinary approach.
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© Copyright 2012 - East and Central African Journal of Surgery
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