![](/imgs/covers/transparent.gif)
|
Indian Journal of Medical Microbiology
Medknow Publications on behalf of Indian Association of Medical Microbiology
ISSN: 0255-0857 EISSN: 0255-0857
Vol. 23, No. 4, 2005, pp. 231-238
|
Bioline Code: mb05071
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Indian Journal of Medical Microbiology, Vol. 23, No. 4, 2005, pp. 231-238
en |
Granulomatous inflammation in acanthamoeba keratitis: An immunohistochemical study of five cases and review of literature
Vemuganti GK, Pasricha G, Sharma S, Garg P
Abstract
Purpose: Acanthamoeba keratitis usually presents as a necrotizing stromal inflammation. We report a rare presentation of granulomatous inflammation in Acanthamoeba keratitis
Methods: Retrospective clinico-pathologic case series.
Results: Five corneal tissues (3 corneal buttons, 2-eviscerated contents) from patients suffering from severe Acanthamoeba keratitis not responding to anti-Acanthamoeba treatment, revealed a florid granulomotous inflammation with multinucleated giant cells in the posterior stroma and around Descemet′s membrane. Phagocytosed parasites were noted within the giant cells. Vascularization of the corneal stroma was noted in two cases. Immunophenotyping revealed a predominance of T lymphocytes and macrophages. Clinically, four of five cases had shown features of limbal and scleral involvement.
Conclusion: Granulomatous inflammation in the posterior corneal stroma, is not an uncommon finding in Acanthamoeba keratitis and could possibly be immune-mediated, contributing to persistence and progression of disease.
Clinical Relevance: Presence of granulomatous inflammation in Acanthamoeba keratitis, in most cases is associated with limbal and scleral involvement and therefore could be considered as one of the poor prognostic markers. Further studies are required to ascertain the specific clinical features and appropriate management strategies in these cases.
Keywords
Acanthamoeba keratitis, Granulomatous inflammation, sclertitis, immunophenotyping
|
|
© Copyright 2005 Indian Journal of Medical Microbiology. Alternative site location: http://www.ijmm.org
|
|