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Indian Journal of Medical Microbiology
Medknow Publications on behalf of Indian Association of Medical Microbiology
ISSN: 0255-0857 EISSN: 0255-0857
Vol. 26, No. 2, 2008, pp. 151-154
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Bioline Code: mb08043
Full paper language: English
Document type: Short Communication
Document available free of charge
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Indian Journal of Medical Microbiology, Vol. 26, No. 2, 2008, pp. 151-154
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Genotypic resistance profile of HIV-1 protease gene: A preliminary report from Vellore, south India
Kandathil, AJ; Kannangai, R; Abraham, OC; Sudarsanam, TD; Pulimood, SA & Sridharan, G
Abstract
HIV-1 subtypes other than B are responsible for most new HIV infections worldwide; virus sequence data for drug resistance is described only from a limited number of non-B subtype HIV-1. This study is on mutations and polymorphisms of HIV-1 protease gene that can predict drug resistance in subtype C. The genotypic resistance assay was carried out on 38 HIV-1 strains with their plasma RNA and in nine, the proviral protease gene was sequenced. The treatment naοve strains showed minor resistance mutations, there were no major resistance mutations in the protease gene. We suggest the use of resistance testing to monitor individuals on therapy and also before initiation of therapy, gathering more sequence information for a data bank of Indian strains.
Keywords
Drug resistance, India, HIV-1, protease gene mutations
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© Copyright 2008 Indian Journal of Medical Microbiology. Alternative site location: http://www.ijmm.org
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