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Indian Journal of Medical Microbiology
Medknow Publications on behalf of Indian Association of Medical Microbiology
ISSN: 0255-0857 EISSN: 0255-0857
Vol. 28, No. 4, 2010, pp. 358-362
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Bioline Code: mb10105
Full paper language: English
Document type: Short Communication
Document available free of charge
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Indian Journal of Medical Microbiology, Vol. 28, No. 4, 2010, pp. 358-362
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Prevalence of hepatitis C virus genotypes and impact of T helper cytokines in achieving sustained virological response during combination therapy: A study from Central India
Mishra, P. K.; Bhargava, A.; Khan, S.; Pathak, N.; Punde, R. P. & Varshney, S.
Abstract
Characterisation of host immune response to hepatitis C virus (HCV) genotypes may have an important prognostic and therapeutic implication. Genotype-3 was more prevalent in the examined cohort and demonstrated a significantly higher response to combination therapy than genotype-1. Sustained virological response (SVR) was 94.74% in genotype-3 and 45.45% in genotype-1. The patients who achieved SVR reported higher levels of circulating T helper 1 cytokines in comparison to subjects with no SVR in both the studied groups. Besides providing local prevalence, our study might also assist in understanding the host immune mechanisms involved to achieve SVR during combination therapy in chronic HCV patients.
Keywords
Antiviral therapy, cytokines, HCV genotypes, hepatitis C virus, molecular surveillance
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© Copyright 2010 Indian Journal of Medical Microbiology. Alternative site location: http://www.ijmm.org
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