|
African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 18, No. 1, 2015, pp. 55-60
|
Bioline Code: md15009
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
African Journal of Biomedical Research, Vol. 18, No. 1, 2015, pp. 55-60
en |
Beneficial Effects of Leaf Extracts of Lycoperscon esculentum on Wound Healing in Rats
Zamide, E.I.; Ajani, R.S. & Oladapo, O.O.
Abstract
The study was aimed at determining the effects of the methanol extracts of the leaves of Lycoperscon esculentum on the wound
healing in Wistar rats. Excisional wounds were inflicted on the upper dorsolateral trunk of normal saline (control) and tomato
(Lycoperscon esculentum) leaf treated (TLT) adult rats and thereafter dressed four times daily for three days. Wound
dimensions along two perpendicular axes were taken prior to dressings for the purpose of estimation of wound contraction
rates. Granulation tissues were excised from five animals in each group and scar tissues obtained from the remaining animals.
Fibroplasia and angiogenesis were evaluated histologically. Matched wound contraction rates were higher in the TLT group.
Duration of healing was shorter in the TLT (19.80 ± 1.64 days) when compared with control (28.80 ± 4.55 days). Fibroblast
counts of granulation tissue were 35.20 ± 17.53 (for TLT) and 24.00 ± 8.00 (for control), with respective angiogenesis counts
of 12.60 ± 8.32 and 15.60 ± 5.77. Respective values for fibroblast and angiogenesis of the scar tissues in experimental and
control groups were 18.40 ± 3.7 vs 20.80 ± 5.21; and 14.20 ± 1.92 vs 13.20 ± 1.64). Histological sections of the granulation
and scar tissues revealed abundance of collagen and paucity of macrophages in the experimental group. Leaf extract of
Lycoperscon esculentum promotes wound healing via bactericidal activity, rapid initiation and acceleration of wound
contraction, increased fibroblast production and collagen synthesis
Keywords
skin wound healing; Lycoperscon esculentum; tomato leaves; fibroplasia; angiogenesis
|
|
© Copyright 2015 - African Journal of Biomedical Research
|
|