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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359 EISSN: 0019-5359
Vol. 59, No. 8, 2005, pp. 353-356
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Bioline Code: ms05053
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Medical Sciences, Vol. 59, No. 8, 2005, pp. 353-356
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Mycophenolate mofetil in neuropsychiatric systemic lupus erythematosus
Jose J, Paulose BK, Vasuki Z, Danda D
Abstract
Neuropsychiatric abnormalities frequently occur in patients with systemic lupus erythematosus, affecting as many as 14-75% of people with this disease. High-dose steroid with or without anticoagulation is the mainstay of treatment in neuropsychiatric systemic lupus erythematosus (NPSLE). Use of mycophenolate as a steroid sparing drug may be a potential alternative agent in the therapy of NPLE, but lack of randomized trials and cost prohibit its widespread use. Its safety profile is higher than that of cyclophosphamide and azathioprine. We report a successfully treated case of neuropsychiatric systemic lupus erythematosus, presenting as psychosis, whose long-term remission was maintained on treatment with mycophenolate mofetil.
Keywords
CNS vasculitis; cyclophosphamide; mycophenolate mofetil; systemic lupus erythematosus
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© Copyright 2005 Indian Journal of Medical Sciences. Alternative site location: http://www.indianjmedsci.org/
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