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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359 EISSN: 0019-5359
Vol. 61, No. 6, 2007, pp. 326-331
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Bioline Code: ms07053
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Medical Sciences, Vol. 61, No. 6, 2007, pp. 326-331
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Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension
Nandeesha, H; Sathiyapriya, V; Zachariah, Bobby; Pavithran, P; Agrawal, Aparna & Selvaraj, N
Abstract
Background : Although a wide number of experimental evidences are available regarding oxidant-antioxidant disturbance in hypertension, clinical data supporting it is lacking in men in early stages of hypertension.
Aims: The objective of the study was to evaluate oxidative status and antioxidant activities in males with stage I essential hypertension.
Materials and Methods : Thirty hypertensives and 21 normotensives were included in the study. Protein carbonyl, reduced glutathione, glutathione peroxidase, catalase and fasting glucose were assessed in both the groups.
Statistical Analysis : Results were analyzed by student′s ′t′ test and linear regression analysis test.
Results : Plasma protein carbonyl and glutathione peroxidase were significantly increased, and catalase and GSH were significantly reduced in the hypertensive group compared to normotensive subjects. There was a significant negative correlation between glutathione peroxidase and catalase in the test group.
Conclusions : The data from the present study indicates an alteration in oxidant-antioxidant status in non-obese men in early stages of essential hypertension.
Keywords
Antioxidants, essential hypertension, oxidative stress
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© Copyright 2007 Indian Journal of Medical Sciences. Alternative site location: http://www.indianjmedsci.org/
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