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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359 EISSN: 0019-5359
Vol. 62, No. 3, 2008, pp. 113-116
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Bioline Code: ms08019
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Medical Sciences, Vol. 62, No. 3, 2008, pp. 113-116
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Neonatal thyroid screening in a mild iodine deficiency endemic area in Iran
Najafi, Mohammad; Khodaee, Gholam Hossein; Bahari, Mohammad; Sabahi, Masoumeh; Farsi, Mostafa Mazlom & Kiani, Fatomeh
Abstract
Background : Evaluated serum thyroid-stimulating hormone (TSH), as an early index for diagnosis of neonatal hypothyroidism, indicates insufficient supply of thyroid hormones. Objective : The aim of the study was to estimate the incidence of neonatal hypothyroidism and assessment of iodine deficiency in the eastern part of Iran. Settings and Design : A cross-sectional study was conducted in a pilot screening. Materials and Methods : The measurement of blood TSH spotted on filter paper was performed by ELISA method in 59,436 neonates. TSH value equal to 5 mU/L was considered cut off point. The diagnosis of hypothyroidism in neonates with the blood TSH higher than the cut off point was based on clinical examinations and laboratory tests (serum TSH and T4). Statistical Analysis: The groups were compared using chi-square and ANOVA tests. Results : In our study, the recall rate and incidence of hypothyroidism were 3.6% and 2 per 1000 neonates respectively. Based on the proposal made by WHO/UNICEF/ICCIDD, the results of our study showed a mild iodine deficiency in the area. Conclusions : A comprehensive policy should be developed for control of iodine deficiency and treatment of hypothyroidism in the studied population and neighboring countries.
Keywords
Filter paper, neonatal hypothyroidism, thyroid-stimulating hormone
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© Copyright 2008 Indian Journal of Medical Sciences. Alternative site location: http://www.indianjmedsci.org/
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