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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359 EISSN: 0019-5359
Vol. 63, No. 2, 2009, pp. 72-75
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Bioline Code: ms09013
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Medical Sciences, Vol. 63, No. 2, 2009, pp. 72-75
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Naloxone-Induced Pulmonary Edema: A Potential cause of Postoperative Morbidity in Laparoscopic Donor Nephrectomy
Nath, SoumyaShankar; Tripathi, Mukesh; Pandey, Chadrakant & Rao, Bhaskar
Abstract
A 28-year-old patient operated for laparoscopic donor nephrectomy (LDN) developed overdose effect of fentanyl leading to poor postoperative recovery. Naloxone (200 µg) treatment was used to reverse fentanyl effects, but it was associated with hypertension. The patient developed pulmonary edema after 2 hours and required overnight mechanical ventilation with positive end-expiratory pressure. Volume overload prescribed in the management of LDN to overcome the immediate poor renal graft functioning probably predisposed this healthy young patient to develop cardiac failure during sympathetic surge associated with naloxone administration. The authors feel that the reversal of overdose effect of opioid by naloxone after intravascular blood volume expansion puts the patient at risk to develop pulmonary edema.
Keywords
Donor nephrectomy, fentanyl, laparoscopic nephrectomy, naloxone, pulmonary edema
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© Copyright 2009 Indian Journal of Medical Sciences. Alternative site location: http://www.indianjmedsci.org/
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