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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359 EISSN: 0019-5359
Vol. 64, No. 12, 2010, pp. 556-559
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Bioline Code: ms10005
Full paper language: English
Document type: Case Report
Document available free of charge
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Indian Journal of Medical Sciences, Vol. 64, No. 12, 2010, pp. 556-559
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Ceftriaxone resistant Shigella flexneri , an emerging problem
Gupta, Soham; Mishra, Baijayanti; Muralidharan, Sethumadhavan & Srinivasa, Hiresave
Abstract
Shigellosis is a disease of public health importance in developing countries. It may cause self-limited diarrhea to severe dysentery. Emergence of multi drug resistant (MDR) strains is a growing concern globally. Ceftriaxone and ciprofloxacin are the drugs of choice for MDR cases. Here, we report a case of MDR Shigella flexnerifrom an immunocompromised patient. The strain was resistant to ceftriaxone [minimum inhibitory concentration (MIC) ≥ 64 μg/ml], limiting the treatment option. Simultaneously, the strain was also found to be resistant to ciprofloxacin (MIC ≥ 4 μg/ml). However, it was susceptible to ceftazidime (MIC 4 μg/ml). This is the first case of ceftriaxone resistant Shigella spp. reported from our hospital.
Keywords
Ceftriaxone, extended spectrum beta lactamase, minimum inhibitory concentration, multi drug resistant, Shigella flexneri
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© Copyright 2010 Indian Journal of Medical Sciences. Alternative site location: http://www.indianjmedsci.org/
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