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Mechanisms Of Cell Accumulation Induced By Mycobacterium Bovis BCG
Menezes-de-Lima-Junior, Octavio & Henriques, Maria das Gracas M.O.
Abstract
Mycobacteria, specially Mycobacterium tuberculosis are among the
micro-organisms that are increasing dramatically the number of infections
with death, all over the world. A great number of animal experimental
models have been proposed to investigate the mechanisms involved in the
host response against these intracellular parasites. Studies of airway
infection in guinea-pigs and rabbits, as well as, in mice intravenously
infected with BCG have made an important contribution to our understanding
of the virulence, pathogenesis and the immunology of mycobacterial
infections. Although, there are few models to study the mechanisms of the
initial inflammatory process induced by the first contact with the
Mycobacteria, and the relevance of the acute generation of inflammatory
mediators, cytokines and leukocyte infiltration to the development of the
mycobacterial infection. In this work we reviewed our results obtained with
a model of M. bovis BCG-induced pleurisy in mice, describing the
mechanisms involved in the leukocyte influx induced by BCG at 24 hr.
Different mechanisms appear to be related with the influx of neutrophils,
eosinophils and mononuclear cells and distinct inflammatory mediators,
cytokines and adhesion molecules are involved in the BCG-induced cell
accumulation.
Keywords
animal models - Mycobacteria - Mycobacterium bovis BCG - inflammation - leukocyte accumulation - pleurisy
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