Intractable seizure in a case with parry-Romberg syndrome and good response to intravenous immune globulin

Objective: Parry-Romberg syndrome is a rare disorder associated with unilateral facial atrophy involving skin, subcutaneous tissue, skeletal muscles and bone. Occasionally, there is central nervous system involvement with epilepsy being the most common manifestation.
Case report: In this article, we report a 12 year-old boy with Parry-Romberg syndrome. He had seizures since he was 5 years old, since 1 year ago the seizure attacks were refractory in spite of taking several antiepileptic drugs. Significant improvement was obtained after administration of intravenous immune-globulin (IVIG).
Conclusion: IVIG may be of benefit when seizures in Parry-Romberg syndrome are intractable and resistant to antiepileptic drugs.

Keywords
parry Romberg syndrome , Intractable Epilepsy , Intravenous Immune globulin , Scleroderma , seizure