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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 41, No. 2, 2009, pp. 72-74
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Bioline Code: ph09021
Full paper language: English
Document type: Research Article
Document available free of charge
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Indian Journal of Pharmacology, Vol. 41, No. 2, 2009, pp. 72-74
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Is cytochrome modulation the new frontier for decreasing the risk of cataract?
Nair, Kavitha S; Patel, Kirti V & Gandhi, Tejal R
Abstract
Aim: The present study was designed to study the effect of cytochrome P450 (CYP) modulators on the occurrence of cataract using male Sprague-Dawley rats weighing 40:50 gm.
Materials and Methods: Macroscopical examination of the lens isolated from rats pretreated with diltiazem (30 mg/kg; once daily; PO) showed delayed occurrence of cataract while pioglitazone (3.8 mg/kg; once daily; PO) pretreatment demonstrated an early cataract.
Results and Conclusion: A delayed occurrence of cataract with diltiazem (CYP inhibitor) and an early onset of cataract with pioglitazone (CYP inducer) indicate that a cytochrome P450 mediated pathway may affect the initiation of cataract but not the maturation pattern.
Keywords
Cataract, cytochrome P450, diltiazem, pioglitazone
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© Copyright 2009 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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