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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 0253-7613
Vol. 42, No. 4, 2010, pp. 243-244
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Bioline Code: ph10069
Full paper language: English
Document type: Case Report
Document available free of charge
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Indian Journal of Pharmacology, Vol. 42, No. 4, 2010, pp. 243-244
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Unusual nail pigmentation following cyclophosphamide-containing chemotherapy regimen
Kumar, Santosh; Dixit, Rakesh; Karmakar, Saurabh & Paul, Sayan
Abstract
Cyclophosphamide therapy may rarely cause pigmentation of the nails which is of different patterns. We report a patient who developed pigmentation of nails after six cycles of cyclophosphamide, methotrexate, and 5-flourouracil chemotherapy, each repeated after 28 days for breast cancer. The patient developed nail pigmentation that started proximally and spread distally and involved all the nails of both hands and feet except the second and third toenails of right foot. Using Naranjo ADR Probability Scale, the case revealed a "probable" association with cyclophosphamide.
Keywords
Chemotherapy, cyclophosphamide, nail pigmentation
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© Copyright 2010 Indian Journal of Pharmacology. Alternative site location: http://www.ijp-online.com
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