Factors Associated with Treatment Response to Antidiabetic Agents in Compliant Type 2 Diabetes Mellitus Patients: A Brief Summary of 5-Year Data

Purpose: To evaluate the response to diabetic medications and factors influencing drug response in compliant type 2 diabetes mellitus (T2DM) patients.
Methods: A cross-sectional, retrospective study was performed on 100 T2DM patients at the University Malaya Medical Centre (UMMC) who were prescribed with at least one antidiabetic medication between January 2007 and December 2011.
Results: Using data from their medical records, it was determined that both fasting plasma glucose (FPG) and glycated hemoglobin (A1c) levels among all subjects were lower than baseline values. However, the reductions were not significant (p = 0.239 and p = 0.093). Factors that were significantly associated with the response to diabetic medications, include hypertension (p = 0.011), sulfonylureas (p = 0.041), beta-blockers (p = 0.005), and baseline A1c levels (p < 0.001).
Conclusion: Treatment of T2DM can be further optimized to ensure that diabetes is well-controlled.

Keywords
Treatment response; Antidiabetics; Type 2 Diabetes Mellitus; Hypertension; Beta-blocker