Purpose: The memory-enhancing effects of
Rhodiola rosea
L. extract (RRLE) on normal aged mice
were assessed.
Methods: In the open-field test, the effect of RRLE (150 and 300 mg/kg) on mouse locomotive activities
was evaluated by investigating the extract’s influence on CAT and AchE activities in the brain tissue of
mice.
Results: Compared with aged group, high dose of RRLE reduced the total distance (3212.4 ± 123.1
cm, p < 0.05) significantly, increased catalase (CAT) activity (101.4 ± 12.2 U/mg pro, p < 0.05), and
inhibited acetyl cholinesterase (AChE) activity (0.94 ± 0.12 U/mg pro, p < 0.05) in the brain tissue of
aged mice.
Conclusion: The results show that RRLE improves the memory functions of aged mice probably by
increasing CAT activity while decreasing AChE activity.
