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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 15, No. 11, 2016, pp. 2351-2356
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Bioline Code: pr16310
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 15, No. 11, 2016, pp. 2351-2356
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A study on expression levels of matrix metalloproteinases and their inhibitors in patients with ulcerative colitis
Huang, Guo-Dong & Xiong, Jing
Abstract
Purpose: To investigate the expression levels of matrix metalloproteinases and their inhibitors in
ulcerative colitis patients
Methods: In this investigation, the expression of matrix metalloproteinases (MMPs) and tissue inhibitors
of metalloproteinases (TIMPs) were evaluated in 50 patients with ulcerative colitis, which comprised of
36 males and 14 females. The tissue samples were obtained from the core needle of sample and
evaluated using immunochemistry techniques.
Results: The prevailing MMP-9 and TIMP-1 expressions in the glandular epithelium and inflammatory
cells were observed. In addition, the expressions were coupled with architectural changes in the tissues
and inflammation in the lamina propria. It was also observed that the expression of MMPs and inhibitors
with weak activation established the progress of ulcerative colitis. Statistical correlation between the
MMP expressions and histopathological parameters was also very significant. MMP expression
correlated with weaker expression of TIMPs.
Conclusion: MMPs, especially MMP-2, MMP-7 and MMP-9, may provide a potential target for
controlling ulcerative colitis.
Keywords
Ulcerative colitis; Matrix metalloproteinases; Tissue inhibitors of metalloproteinases; Lamina propria; Inflammation
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