Purpose: To synthesize and evaluate Schiff base Tin (II) complexes for antioxidant and antimicrobial
activities
Methods: The complexes of Tin (II) chloride with various Schiff base derivative of 2-Hydroxy-1-naphthaldehyde (HN) were synthesized and characterized by various physiochemical techniques,
including elemental analysis, ultraviolet–visible (UV-Vis) spectrophotometry, Fourier transform infrared
spectroscopy (FTIR), proton nuclear magnetic resonance (
1H–NMR), carbon-13 nuclear magnetic
resonance (
13C-NMR), electron ionization mass spectrometry (EIMS) and conductance studies. Agar-well
diffusion and agar-well dilution techniques were used for antimicrobial assessment. Evaluation of
the antioxidant activity of the ligands and complexes was accomplished by DPPH radical scavenging
assay.
Results: The results indicate coordination of deprotonated phenolic oxygen and nitrogen of azomethine
with Tin (II) chloride led to the formation of stable complexes. The Tin (II) complexes showed good
antimicrobial and antioxidant activities. Compounds (HNPA and [Sn(HNPA)Cl
2(H
2O)
2) were noteworthy
(p < 0.05) in this regard with antibacterial activity against
Staphylococcus aureus
, while
[Sn(HNCA)Cl
2(H
2O)
2 and [Sn(HNPT)Cl
2(H
2O)
2 were active against
Klebsiella pneumoniae
..
Conclusion: All synthesized Schiff bases and their Tin (II) complexes showed high antimicrobial and
antioxidant activities than their corresponding ligands.