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Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 4, No. 1, 2005, pp. 70-71
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Bioline Code: pt05015
Full paper language: English
Document type: Research Article
Document available free of charge
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Iranian Journal of Pharmacology and Therapeutics, Vol. 4, No. 1, 2005, pp. 70-71
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Hyperpigmentation of the Skin Following Chloroquine Treatment - Case Series Report
PANAMBOOR SABITHA, MATTI PRABHA ADHIKARI and MARIA KURUVILLA
Abstract
In this article, we are collectively presenting case reports of 15 patients who developed pigmentary changes of the skin and mucus membrane during the course of chloroquine therapy for connective tissue disorders. These female patients developed hyper pigmentation of the skin, largely on the exposed parts of the body. The pigmentary changes varied from brownish/ grayish/ bluish-black in color, patchy or diffuse, intense or mild. The shortest time lag between onset of chloroquine therapy and development of pigmentary changes was 3 months. The patients should be informed about this cosmetically important toxic effect of chloroquine and advised to avoid direct exposure to sunlight.
Keywords
Chloroquine, Hyperpigmentation of skin, Connective tissue disorder
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© Copyright 2005 - Razi Institute for Drug Research (RIDR) Alternative site location: http://ijpt.iums.ac.ir/
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