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Iranian Journal of Pharmacology and Therapeutics
Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
ISSN: 1735-2657
Vol. 4, No. 2, 2005, pp. 143-145
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Bioline Code: pt05030
Full paper language: English
Document type: Research Article
Document available free of charge
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Iranian Journal of Pharmacology and Therapeutics, Vol. 4, No. 2, 2005, pp. 143-145
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Frequency of Sodium Valproate-Induced Hair Loss and Curly Hair
HOSEINALI EBRAHIMI, SADOLLAH SHAMSADINI and SHAHRIAR SADRE ESHKAVARI
Abstract
Sodium valproate has been widely used by man as an antiepileptic drug. Hair loss and curly hair is a rare side effect of sodium valproate. We have conducted a prospective clinical study in the Department of Neurology in Shafa Hospital, Kerman, Iran for ten years (1994-2004). All 211 epileptic patients in our study were given sodium valproate as a single drug treatment. During the course of therapy, all patients were strictly monitored every 3 months. Six cases (3.5% of valproate user population) of hair loss and curling of hair were found between sodium valproate users. Three cases were female and three were male. This side effect observed at least 3 months after its first initial drug therapy. The estimated fre-quency of curly hair along with hair loss in our study is lower than previously-reported frequencies (6-12%).
Keywords
Curly hair, Sodium valproate, Epilepsy
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