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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 13, No. 6, 2015, pp. 373-378
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Bioline Code: rm15052
Full paper language: English
Document type: Short Communication
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 13, No. 6, 2015, pp. 373-378
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Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome
Moti, Mahtab; Amini, Leila; Sadat Ardakani, Soheila Mirhoseini; Kamalzadeh, Sara; Masoomikarimi, Masoomeh & jafarisani, Moslem
Abstract
Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes. Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran. Materials and Methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples. Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women. Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.
Keywords
Polycystic ovary syndrome; Infertility; CRP; Antioxidant; AOPP
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