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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 14, No. 9, 2016, pp. 557-566
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Bioline Code: rm16072
Full paper language: English
Document type: Review Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 14, No. 9, 2016, pp. 557-566
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GnRH agonist trigger versus hCG trigger in GnRH antagonist in IVF/ICSI cycles: A review article
Alyasin, Ashraf; Mehdinejadiani, Shayesteh & Ghasemi, Marzieh
Abstract
Routinely, a bolus of 5.000-10.000 IU human chorionic gonadotropin (hCG) is used
for the final follicular maturation and ovulation as a standard method. HCG has the
same effect of luteinizing hormone (LH) with long half-life. It has the long
lutheotrophic effect which increases the risk of ovarian hyper stimulation syndrome
(OHSS). Recently, gonadotropin-releasing hormone agonist (GnRH-a) trigger has
been used for the induction of final follicular maturation and ovulation with the aim
of reducing the OHSS risk. Several studies have shown that the releases of
endogenous follicular stimulating hormone (FSH) and LH after administration of
GnRH agonist in in vitro fertilization (IVF) cycles are able to precede the final
follicular maturation leading to removal of fertile oocyte with normal development
of the embryo and ultimately pregnancy. But based on the results of some studies,
using GnRH-a trigger leads to defect luteal-phase resulting to reduce the
implantation and clinical pregnancy rates and also increase abortion in fresh embryo
transfer cycles compared to routine IVF cycle with hCG triggering . Also, in recent
years, studies have continued to modify the luteal phase support, so that the fresh
embryo transfer is possible too. In this review, we examined the benefits, problems,
and also ways to reform GnRH agonist triggering complications.
Keywords
Gonadotropin-releasing hormone; Human chorionic gonadotropin; IVF/ICSI cycles.
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© Copyright 2016 - Iranian Journal of Reproductive Medicine Alternative site location: http://www.ijrm.ir
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