![](/imgs/covers/rm_cover.jpg)
|
International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 7, 2020, pp. 539-550
|
Bioline Code: rm20058
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
International Journal of Reproductive BioMedicine, Vol. 18, No. 7, 2020, pp. 539-550
en |
Semen analysis of subfertility caused by testicular carcinoma
Ghasemi, Behrooz; Mehrjardi, Alimohammad Mosadegh; Jones, Carolyn & Ghasemi, Nasrin
Abstract
Background: Infertility is a common problem in testicular cancer. Affected men often
decide to undergo sperm banking before chemo/radiotherapy. The cumulative effects
of therapy can considerably reduce fertility.
Objective: Testicular cancers impair fertilizing ability, even before diagnosis. This study
tries to verify individual traits and semen quality in patients with testicular cancer.
Materials and Methods: This observational study analyzed 190 semen of patients
with testicular cancer (16 to 47 yr old) referred to the sub-fertility laboratory at the St.
Mary hospital for semen banking prior to treatment carcinoma. Several aspects of their
semen analyses were examined. The cases were divided into four different categories:
seminoma, teratoma, mixed germ cell tumors and others.
Results: The results showed that 23 cases were azoospermic, and 13 of the patients
who were not azoospermic, their sperm of “normal” morphology were too few to count.
Among patients that could produce spermatozoa, 59.4% had a sperm concentration of
< 20 × 106/ml. The mean of “motility excellent” and “sluggish” taken together in all
the cases was 47.2%. More than 92% of the patients had an abnormal morphology.
The morphology of sperm is the most sensitive semen parameter that is affected by
testicular carcinoma.
Conclusion: Abnormal spermatogenesis is seen in most patients with testicular cancer
before treatment with radiation, chemotherapy, or surgery. The causes of poor semen
quality in cancer patients are not well-understood, but the patients with impaired
spermatogenesis should have precise examination to find out the correct diagnosis
of problem and preserve the fertility before any treatment.
Keywords
Infertility; Testicular cancer; Semen analyses; Spermatogenesis.
|
|
© Copyright 2020 - International Journal of Reproductive BioMedicine Alternative site location: http://www.ijrm.ir
|
|