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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 4, 2021, pp. 333-338
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Bioline Code: rm21031
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 4, 2021, pp. 333-338
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Matrix metalloproteinase-9 is elevated and related to interleukin-17 and psychological stress in male infertility: A cross-sectional study
Mary, Ann Prasad; Nandeesha, Hanumanthappa; Papa, Dasari; Chitra, Thyagaraju; Ganesh, Rajesh Nachiappa & Menon, Vikas
Abstract
Background: Matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17) and
psychological stress are known to play a role in the pathogenesis of male infertility.
Objective: To assess the association of MMP-9 with IL-17 and psychological stress
in infertile men.
Materials and Methods: In this cross-sectional study, 39 men with infertility diagnosed
based on semen analysis and 39 subjects with normal semen analysis were included
in the study. MMP-9 and IL-17 were estimated in both groups by ELISA. Perceived stress
scale was used to assess psychological stress in controls and cases.
Results: In infertile cases, MMP-9 and IL-17 were significantly increased when compared
with controls (p = 0.046, p = 0.041 respectively). A significant association of MMP-9 was
observed with IL-17 (r = 0.335, p = 0.037) and perceived stress scale (r = 0.329, p =
0.041).
Conclusion: IL-17 and stress increase MMP- 9 levels in infertile men.
Keywords
Infertility; Interleukins; Peptide hydrolase.
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© Copyright 2021 - Mary et al. Alternative site location: http://www.ijrm.ir
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