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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 9, 2021, pp. 811-820
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Bioline Code: rm21084
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 9, 2021, pp. 811-820
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Maternal aerobic running during mid or late gestation improves the quality of oogenesis and folliculogenesis in the ovary of neonatal rats: An experimental study
Yousefi, Behpour; Baradaran, Raheleh; Mokhtari, Tamineh; Semnani, Vahid & Sameni, Hamidreza
Abstract
Background: Regular maternal exercise in pregnancy enhances the physiological,
metabolic, and psychological health of mother and fetus.
Objective: To determine the effect of maternal aerobic running during mid or
late gestation on plasma levels of estrogen and progesterone and the histological
alterations in the ovary of neonatal rats.
Materials and Methods: Twenty-one female Wistar rats were randomly divided into
experimental groups to exercises during the 2nd or 3rd wk of pregnancy (n = 14) and a
control group (n = 7). After birth, the neonate’s blood was obtained and the estrogen
and progesterone levels were evaluated. The ovaries were then removed and used for
histological investigations and apoptic assessment.
Results: Higher concentrations of estrogen and progesterone were found in the
neonates of the experimental groups (p = 0.001) compared to the control group.
The experimental groups had a large ovarian diameter (2nd wk: p = 0.044; 3rd wk:
p = 0.005) and angiogenesis (2nd wk: p = 0.003; 3rd wk: p = 0.001). In addition, significant
enhancements were seen in the the experimental groups in terms of the number (2nd
wk: p = 0.017; p = 0.035) and diameter (2nd wk: p = 0.046; 3rd wk: p = 0.004) of primordial
follicles, as well as in the diameter of primary oocytes (2nd wk: p = 0.073; 3rd wk:
p = 0.019) compared to the control group. Moreover, rats that exercised had a lower
number of apoptotic primordial follicles than the control group (2nd wk: p = 0.001; 3rd
wk: p = 0.001).
Conclusion: It was shown that maternal aerobic running can lead to increased plasma
levels of estrogen and progesterone, also improved histological characteristics of the
ovary in neonatal rats.
Keywords
Apoptosis; Exercise; Neonatal; Oogenesis; Ovary; Rat.
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