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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 9, 2021, pp. 845-850
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Bioline Code: rm21088
Full paper language: English
Document type: Short Communication
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 9, 2021, pp. 845-850
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CAG repeat polymorphism in androgen receptor and infertility: A case-control study
Sharestani, Shiva; Kalantar, Seyed Mehdi; Ghasemi, Nasrin & Yazd, Ehsan Farashahi
Abstract
Background: Androgens play a role in the development of male phenotype and
spermatogenesis during puberty, the function of which is regulated by the androgen
receptor (AR) gene. There is a polymorphism site in exon 1 of the gene encoding this
receptor that can have different frequencies of CAG trinucleotide repeats and leads to
the formation of polyglutamine chains of different lengths in the N-terminal domain of
the AR protein and reduced sperm production by affecting spermatogenesis.
Objective: To investigate whether the cause of a group of unexplained infertilities
could be the increased frequency of CAG repeats in the AR gene of patients with
oligozoospermia and azoospermia.
Materials and Methods: In this case-control study, 84 men including 42 with
unexplained infertility As a case group and 42 fertile men as a control group were
selected. The frequency of CAG repeats was determined by the polymerase chain
reaction method and then the difference in the frequency of these repeats was
determined based on the difference in band size on the agarose gel.
Results: The mean CAG repeat length in the azoospermia and oligozoospermia group
was 17.5 ± 0.63 and in the fertile group it was 16.11 ± 0.75 (p = 0.46). In addition, most
men (88.1% in the case group and 71.41% in the control group) had 13-23 repeats.
Conclusion: No significant correlation was found between CAG repeat length and the
risk of male factor infertility in an ethnically defined population of Iranian men. The role
of regulatory factors and epigenetic changes should be taken into account too.
Keywords
Infertility; Azoospermia; Androgens; X chromosome; Spermatogenesis.
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